chr16 · 16q24.3 · 290 nt · 2012

ANKRD11 HARs

What it is

Some HAR-bearing genes are managers of managers — they open or close chromatin for many other genes. A human-specific switch at that level can ripple.

Why it matters

Chromatin-regulator cis architecture.

Operator load

• 01 · ΔE

  Enhancer activity

  These stretches of DNA do not code for proteins. They act as volume knobs — turning nearby brain-development genes up or down at the right moment.

• 02 · C

  Compensatory substitution

  When one letter in the sequence changes, another often changes to keep the whole switch working. Evolution rewired the circuit without breaking it.

HAR catalogs · KBG locus literature